A £150,000 scheme to resurface parts of the A595 started on Thursday.
Highways England is carrying out the work between Parton and Pelican Garage and between Bigrigg and West Lakes Science Park.
Road markings and reflective road studs will also be renewed.
The £79,500 project near Parton will take about a week, with temporary traffic lights in place between 8pm and 6am and a 40mph speed limit in place past the road works.
A £70,000 week-long scheme around West Lakes Science Park will follow immediately after, with temporary traffic lights being used between 6pm and 6am and a 40mph speed limit in place past the roadworks.
Both projects will require the overnight closure of side roads from time to time with signed diversion routes in place.
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